This lecture will delve into the science behind weight loss, exploring the biological mechanisms that regulate body weight and the various strategies for effective weight management. Jillian will examine how factors such as hormones and genetics contribute to weight gain and loss, and discuss evidence-based approaches including diet, exercise, and behavioral changes. A special focus will be given to GLP-1 receptor agonists, a class of medications increasingly used in the treatment of obesity. She'll explain simply how these drugs work in aiding weight loss and the potential risks and side effects. By the end of the lecture, participants will have a comprehensive understanding of how to facilitate safe lasting weight loss and the role of GLP-1 drugs within this framework.